http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105061328-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-32 |
| filingDate | 2015-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105061328-B |
| titleOfInvention | A kind of process for purification of olaparib |
| abstract | The present invention provides a kind of process for purification of olaparib, comprises the following steps：A) olaparib crude product is dissolved in amide solvent, obtains olaparib crude product solution；B) by the step A) obtained olaparib crude product solution carries out crystallization, obtain olaparib highly finished product.Process for purification provided by the invention employs amide solvent, amide solvent has preferable solubility to disubstituted impurity in products, it is but poor to the dissolubility of olaparib, process for purification provided by the invention can not only effectively remove the disubstituted impurity in products in olaparib, and also have preferable removal effect to other impurity.Test result indicates that in the olaparib highly finished product that process for purification provided by the invention obtains, the content of disubstituted impurity only has 0.03%, and always miscellaneous is 0.06%. |
| priorityDate | 2015-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.