http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105061295-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd74f44d4e64ebb9c0d11c36c7045631 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-76 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-76 |
| filingDate | 2015-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06fe09c7972d21eb58154ebe78fe8ae5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8211a2291ba9a1c47369c9afab751cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bed3051b859e87a2d6d2e090ff57c00 |
| publicationDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105061295-A |
| titleOfInvention | Synthetic method for lurasidone precursor compound (3AR,4S,7R,7AS) 4,7-methylene-1H-isoindole-1,3(2H)-diketone |
| abstract | The present invention relates to the chemical field, and discloses a synthetic method for a lurasidone precursor compound (3AR,4S,7R,7AS) 4,7-methylene-1H-isoindole-1,3(2H)-diketone. According to the present invention, a compound (reference to the specification) is used to synthesize the lurasidone precursor compound (3AR,4S,7R,7AS) 4,7-methylene-1H-isoindole-1,3(2H)-diketone by inversion of configuration at the temperature of 170-180 DEG C, and a yield of the lurasidone precursor compound (3AR,4S,7R,7AS) 4,7-methylene-1H-isoindole-1,3(2H)-diketone can reach 90%; and in a reaction for preparing the compound (reference to the specification), the operation is simple, the reaction time is short, and a yield can reach 98%; and in a whole synthesis route that takes dicyclopentadiene as an initiator, a noble catalyst and a reagent with great environmental contamination are not used, so that the whole synthetic process is not only light in pollution, easy in treatment, but also has a lowest yield of 90% in each step; and the total yield can be about 83.8%. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114685349-A |
| priorityDate | 2015-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.