http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105061230-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-48 |
| filingDate | 2015-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105061230-B |
| titleOfInvention | Method for preparing dapoxetine hydrochloride |
| abstract | The invention relates to the field of medicines, and in particular relates to a method for preparing dapoxetine hydrochloride. The method comprises the following concrete steps: (1) by taking chiral L-phenylalanine hydrochloride as a starting material, and reducing by adopting a reducing system to obtain an intermediate II; (2) performing Eschweiler-Clark reaction on the intermediate II and paraformaldehyde or formaldehyde to obtain an intermediate III; and (3) performing Williamson aethrization reaction on the intermediate III and 1-naphthaline to obtain the dapoxetine hydrochloride. According to the invention, chiral L-phenylalanine hydrochloride is used as the raw material, so resolution of a product is avoided, the raw material is easily obtained and relatively low in price, conventional equipment can meet production requirements, expensive and virulent reagents are not used, reaction conditions are mild, pollution is little, control is easy and industrialized production is facilitated. |
| priorityDate | 2015-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 139.