http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105038769-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 |
| filingDate | 2015-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105038769-B |
| titleOfInvention | Fluorescent probe based on 8-aminoquinoline derivative and synthetic method and application thereof |
| abstract | The invention discloses a fluorescent probe based on an 8-aminoquinoline derivative and a synthetic method and application thereof. The structural formula of the fluorescent probe is shown in the specification. The specific preparation method comprises the steps that acetonitrile is used as a solvent, raw materials comprising 2-chlorine-N-(quinoline-8-base) acetamide and 2-propargylamine are fed at the mole ratio being 1:1-1.5:1, a certain amount of KI and N, N-DIPEA are added, backflowing is carried out overnight, pressure is reduced, acetonitrile is obtained in a back-out mode, ethyl acetate is extracted, anhydrous sodium sulfate drying is carried out overnight, filtering is carried out, ethyl acetate is obtained in a back-out mode, the obtained oily matter is purified through silica gel column chromatography, the ethyl acetate and petroleum ether with the ratio being 1:1-1.5(v/v) is used as eluent for separation, and a light yellow solid compound L is obtained. The fluorescent probe based on the 8-aminoquinoline derivative has the advantages of being easy to synthesize, good in water solubility, capable of recognizing Zn＜2+＞ in a water environment system and a biological cell system, capable of monitoring, analyzing and tracking sulfur ions and pyrophosphate ions and good in sensitivity. |
| priorityDate | 2015-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.