abstract |
The present invention provides the asymmetrical duplex RNA molecules that can realize sequence specific gene silence.The RNA molecule includes the first chain and the second chain.First chain is longer than the second chain.The RNA molecule includes the double stranded region formed by the first chain and the second chain and independently selected from two ends of 5' jags, 3' jags and blunt end.The RNA molecule of the present invention may be used as research tool and/or therapeutic agent. |