http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105017284-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f1844a243cb198e19b81237d1d1ecdfb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 |
| filingDate | 2015-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_467da6bdcfbcf8e6ad7025eab72494c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff2e203e396f8a84b7eca9f7ea9613e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f2b6211de22f63d7925dd06d01b4797 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0709185a3dd033271519e181cdd07be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcad17203b02ac95f1d9ce0f1ff5a468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef59c9321cb2975ac3416ef9fe0622ba |
| publicationDate | 2015-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105017284-A |
| titleOfInvention | The preparation method of ceftizoxime propivoxil and its intermediate and the preparation method of the intermediate |
| abstract | The invention discloses a method for preparing ceftizoxime propivoxil by using a mixed acid anhydride method, an intermediate 3a/3b/3c and a preparation method for the intermediate. React aminothioxime acetates with BOC-alanine by mixed anhydride method in an organic solvent, and then hydrolyze under organic alcohol conditions to generate intermediates 3a/3b/3c, which are carried out with 7-ANCA in an organic solvent Condensation reaction, esterification to obtain BOC-alanyl ceftizoxime acid, react with halogenated pivalate methyl ester in the presence of acid binding agent to prepare BOC-alanyl ceftizoxime valproxil, remove BOC Protecting group, concentrated and crystallized in an organic solvent to obtain the target compound ceftizoxime propivoxil. The invention has the characteristics of cheap and easy-to-obtain raw materials, mild reaction conditions, less by-products, reliable purity, high yield, and easy large-scale industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112480026-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108440570-A |
| priorityDate | 2015-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.