| abstract |
The invention relates to a preparation method of NK-1 receptor antagonist and its intermediate. The present invention provides a kind of (5S,8S)-8-{[1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy]-methyl}-8-phenyl-1, The preparation method of 7-diaza-spiro[4,5]decan-2-one (compound of formula I), which is prepared from the compound of formula II, also provides the compound of formula II and its preparation method. The method of the invention has the advantages of simple and convenient operation, mild reaction conditions, high safety factor, few side reactions, high yield and high purity, reduces production cost and operation risk, and is very suitable for large-scale industrial production. |