http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105017238-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 |
| filingDate | 2015-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105017238-B |
| titleOfInvention | A kind of method that chiral spiro-phosphate catalyzes and synthesizes the ketone derivatives of 1,4 benzoxazines of optical activity 2H 2 |
| abstract | Optical activity 2H 1 is catalyzed and synthesized the invention discloses a kind of chiral spiro-phosphate, the method of the ketone derivatives of 4 benzoxazine 2, including using benzoxazinone compound and azole compounds as raw material, using chiral spiro-phosphate catalyst as catalyst, react in organic solvent complete, prepare the ketone derivatives of 2H Isosorbide-5-Nitraes benzoxazine 2.The present invention intends utilizing 2H 1 of the asymmetry catalysis azepine Friedel-Crafts reaction method synthesizing optical activity containing trifluoromethyl season Stereocenter, the ketone derivatives of 4 benzoxazine 2, reaction condition is gentle, technique is simple, simple operation, products therefrom has potential good bioactivity, and this will be significant to new medicament screen, while obtained chipal compounds can be used as the intermediate of pharmaceutical synthesis. |
| priorityDate | 2015-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.