http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105017222-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2015-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105017222-B |
| titleOfInvention | A kind of preparation method of Imatinib impurity |
| abstract | The invention discloses a kind of preparation method of Imatinib impurity.This method is with 1; 4 pairs of (4 carboxybenzyl) piperazines are raw material; in N; N DICs, 1 hydroxybenzotriazole, N; N diisopropylethylamine with Imatinib amine react under conditions of existing obtains double [4 [4 methyl 3 [[base of 4 (base of the pyridine 3) pyrimidine 2] amino] phenyl] carbamoyl] benzyl diethylenediamines of Imatinib impurity Isosorbide-5-Nitrae.The preparation method of the present invention is simple, and reaction condition requires low, and the purity of product is high, high income, suitable industrialized production.The impurity of synthesis can be used for the Qualitative and quantitative analysis of impurity, so as to improve the drug safety of Imatinib. |
| priorityDate | 2015-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.