abstract |
The invention discloses a synthetic method for preparing non-peptide p53-MDM2 binding inhibitor dihydroxyisoquinoline derivatives. The method comprises the following steps: compound 1 and compound 2 are reductively aminated to obtain compound 3, and then compound 1 is obtained through substitution, oxidation, reductive amination and deprotection amidation. The invention adopts a brand-new synthesis route, has the advantages of simple operation, high yield, good safety, environmental friendliness, low cost and is beneficial to technological production. |