| abstract |
Compounds represented by formula (I) and acid addition salts thereof, wherein the hydrogen atoms shown to be connected to the pyrazole and benzimidazole rings are respectively connected to one of the nitrogen atoms of the pyrazole or benzimidazole rings; R represents -XQP, wherein X does not exist or represents -CH 2 -, -C(O)- or -C(O)NH-(CH 2 ) k -, wherein k is 0, 1 or 2; Q is selected from Q1, Q2 , Q3, Q4 and Q5, P does not exist or represents straight or branched C1-C3 alkyl, -(CH 2 ) l -NR 2 R 3 or -(CH 2 ) m -C(O)-NR 2 R 3 , wherein l and m independently represent 0, 1 or 2 , the condition is that when B in Q1 represents an oxygen atom, P does not exist; and R2 and R3 independently represent C1 or C2 alkyl, R2 and R 3 together with the nitrogen atom to which they are both attached form a 6-membered saturated heterocyclic ring, wherein one of the carbon atoms may optionally be replaced by -O-, -NH- or -N(C1-C2)alkyl. The compounds can be used in the treatment of cancer diseases. |