http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105001220-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2015-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105001220-B |
| titleOfInvention | Preparation method of indoloquinoline alkaloid analogues |
| abstract | The invention belongs to the field of alkaloid analogues and particularly relates to a preparation method of indoloquinoline alkaloid analogues. The preparation method comprises the following steps that 1, a base catalyst is dissolved in water and isatin or substituted isatin is added into the water and subjected to a reaction to form a phase; 2, a solvent and substituted -2-chlorine-3-acetylindole are added, and the mixture is subjected to oil bath heating to 100-130 DEG C and is irradiated through an incandescent lamp; 3, a reaction system is cooled to the room temperature, the reaction mixture is poured into ice water, the pH is adjusted through a hydrochloric acid solution, produced sediment is subjected to pumping filtration, washing, drying and methyl alcohol recrystallization, and then a target product is obtained. The preparation method has the advantages that the number of the total synthesis procedures is small, cost is low, and the yield is high; the yield is increased to 58.2-69.5% from original 22-45%. |
| priorityDate | 2015-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.