http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105001101-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-68 |
| filingDate | 2015-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105001101-B |
| titleOfInvention | A kind of synthetic method of the trifluoroacetyl aniline hydrate hydrochloride of 4 chlorine 2 |
| abstract | The present invention relates to a kind of synthetic method of efavirenz intermediate, and in particular to a kind of synthetic method of the trifluoroacetyl aniline hydrate hydrochloride of 4 chlorine 2, belongs to pharmaceutical intermediate synthesis technical field.Synthetic method comprises the following steps：N-butyllithium solution is added drop-wise in 4 chlorine N pivaloyl group aniline solutions under low temperature; reaction obtains double lithium salt solutions of 4 chlorine N pivaloyl group aniline; then trifluoro-acetyl chloride gas reaction is passed through under low temperature into solution and obtains the trifluoroacetyl group N pivaloyl group aniline of 4 chlorine 2, finally hydrolyzes to obtain the trifluoroacetyl aniline hydrate hydrochloride of 4 chlorine of product 2 in acid condition by the trifluoroacetyl group N pivaloyl groups aniline of 4 chlorine 2.Present invention n-BuLi makees alkali, is converted to the lithium chloride solution of the high economic value of comparison substantially with after in hydrochloric acid, is easily recycled processing, can reduce sewage disposal difficulty；Make raw material using cheap trifluoro-acetyl chloride, production cost can be reduced. |
| priorityDate | 2015-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.