http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104987504-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 |
| filingDate | 2015-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104987504-B |
| titleOfInvention | Pegylation Lapatinib and its injection and preparation method |
| abstract | The present invention provides Pegylation Lapatinib and its injection and preparation method.Pegylation Lapatinib, its general formula are： A is selected from single armed or the polyethylene glycol of multi-arm or the derivative of polyethylene glycol；X is selected from Y and M is separately selected from double carboxylic acids with amino or corresponding acyl group substituent；N is selected from amino acid or peptide；LPT is Lapatinib；A=0 or 1；B=0 or 1；C=1 or 2；D=1 or 2；E is equal to the arm number of X.The present invention has synthesized the pegylated medicament of Lapatinib, reduces the toxicity of Lapatinib, improves its water-soluble and biological stability, avoids the drug resistance of cancer cell and cancer stem cell, enhance targeting, significantly improve anticancer therapeutic. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3228650-A4 |
| priorityDate | 2015-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.