http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104987323-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2015-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104987323-B |
| titleOfInvention | A kind of preparation method of dabigatran etcxilate |
| abstract | The present invention relates to a kind of preparation method of dabigatran etcxilate, in the preparation process of the present invention, replace to use in the prior art and expensive N with acyl chlorides or acid anhydrides, N ' carbonyl dimidazoles (CDI) or palladium carbon, greatly reduce cost, and used raw material is cheap and easily-available, simple for process, simplify post-processing step, purified in whole operation step without using column chromatography, simplify whole preparation method technique, be easy to implement industrialization；The present invention is in the compound of synthesis type 2, using Sodamide and ammonium salt system, it is to avoid the generations of a large amount of acid pickles, not only production safety, environmentally safe, also makes preparation process simple and easy to do；In 1 compound of synthesis type, the stable compound of formula 7 of property is employed, is brought great convenience to production, and effectively increase the yield of dabigatran etcxilate, the total recovery that the present invention prepares dabigatran etcxilate reaches 60~70%. |
| priorityDate | 2015-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.