http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104983675-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-10 |
| filingDate | 2015-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104983675-B |
| titleOfInvention | A kind of Tretinoin ethosome gel and preparation method thereof |
| abstract | The invention discloses a kind of Tretinoin ethosome gel, the grain size of Tretinoin alcohol plastid is 130~200nm in gelling agent, and the encapsulation rate of Tretinoin alcohol plastid is more than 90%.The invention also discloses the preparation method of the gelling agent, the specific steps are：Crude Tretinoin alcohol plastid suspension is prepared, it is ultrasonically treated, with 0.22 μm of membrane filtration, obtains Tretinoin alcohol plastid；Prepare gelinite；Alcohol plastid is mixed with gelinite, to get Tretinoin ethosome gel after development.The present invention wraps up Tretinoin compared with liposome Tretinoin using alcohol plastid, there are better stability and percutaneous absorbability, the Tretinoin ethosome gel of preparation is external transdermal drug-delivery preparation, it is reducing to the irritating of skin while transdermal penetration effect can be enhanced, permeation enhancers containing definite composition in gelling agent further enhance the transdermal penetration effect of Tretinoin ethosome gel. |
| priorityDate | 2015-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.