http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104974154-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2014-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104974154-B |
| titleOfInvention | Hirsutine analogue and application thereof in preparation of anti-hypertensive drugs |
| abstract | The invention belongs to the field of traditional Chinese medicine production and relates to a traditional Chinese medicine uncaria extract, namely hirsutine analogue compound with the structure represented by formula (1) and application of the hirsutine analogue compound in the preparation of anti-hypertensive drugs. An experiment proves that the hirsutine analogue compound has remarkable pharmacological actions of resisting hypertension and vascular dilation. A spontaneously hypertensive rat (SHR) experiment proves that the blood pressure and the heart rate of an SHR are obviously decreased after 30 minutes of administration, and the blood pressure of the spontaneously hypertensive rat can be rapidly and effectively decreased; an in-vitro vascular ring vasomotion experiment proves that by virtue of an extremely low dose of the hirsutine analogue compound, the vascular ring contraction caused by phenylephrine can be remarkably dilated. The hirsutine analogue compound can be used as a raw material of a pharmaceutical preparation, is further used for preparing drugs for treating hypertension and is particularly used for preparing vascular dilation drugs for treating hypertensive emergencies. |
| priorityDate | 2014-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.