| abstract |
The invention provides a 2,4,5-multi-substituted imidazole compound, which is a functionalized imidazole compound synthesized by selectively reacting olefin azide and substituted carbazate under heating conditions. The preparation method is simple to operate, the raw materials are easy to obtain, multiple substituents can be introduced simultaneously, and the product is easy to separate. The 2,4,5-multi-substituted imidazole compound prepared by the invention has a certain activity of inhibiting tumor cells in vitro, and can be used as an anti-tumor lead compound. Its structural formula is: . |