http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104974061-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_849a7f5c4926779612c9b8d3c8c36355 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C245-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-36 |
| filingDate | 2014-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a4754d1896856b14299404bcf96e78a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca05dc84ccfcec4263ec0cd2eed9533d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01162ddb4d8b9579a39874c59089659b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e7ad91d86391452ce14a7e01d84264f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_515437c400c3b09fe8237be803d1bcb7 |
| publicationDate | 2015-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104974061-A |
| titleOfInvention | Preparation method of balsalazide disodium |
| abstract | The invention relates to a preparation method of balsalazide disodium, which includes following steps: (1) with paranitrobenzoyl chloride as a raw material, performing a reaction with [beta]-alanine in a NaOH water solution to obtain paranitrobenzoyl-[beta]-alanine; (2) with hydrazine hydrate as a reduction agent, FeCl3.6H2O as a catalyst and water as a solvent, performing a reduction to the paranitrobenzoyl-[beta]-alanine to obtain paraminobenzoyl-[beta]-alanine; (3) performing a diazo-reaction and a coupling reaction to the paraminobenzoyl-[beta]-alanine to obtain balsalazide acid; and (4) performing a salt forming reaction to the balsalazide acid to obtain balsalazide disodium. In the invention, the reduction reaction is carried out with hydrazine hydrate as the reduction agent, FeCl3.6H2O as the catalyst and water as the solvent, so that an expensive Pd-C catalyst is replaced and usage of hydrogen is canceled, so that the preparation method is greatly improved in operation safety and reduced in synthetic cost. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108997165-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108997165-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115417785-A |
| priorityDate | 2014-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.