http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104974017-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-40 |
| filingDate | 2014-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104974017-B |
| titleOfInvention | The preparation method of (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine D-mandelate |
| abstract | The invention discloses a preparation method of (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine D-mandelic acid salt. The method can obtain the compound of formula V through cyclopropanation reaction The compound of formula IV is amide-formed and Hofmann degraded to obtain the compound of formula II, and then salt-formed with D-mandelic acid to obtain the compound of formula I. The preparation method of the compound of formula V is to obtain the compound shown in formula V through CBS asymmetric reduction reaction of the compound shown in formula VI, and the catalyst of the asymmetric reduction reaction of CBS is the structure shown in formula VII The compound, the reducing agent of the CBS asymmetric reduction reaction is selected from borane-tetrahydrofuran or borane-N,N-diethylaniline. |
| priorityDate | 2014-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.