| abstract |
The present invention relates to 1,2-diazine derivatives and their preparations and uses. The 1,2-diazine derivatives have the chemical structural formula shown in general formula I: ; Wherein, R 1 represents a substituent, which is H, C 1 -C 4 saturated alkyl, C 3 -C 6 cycloalkyl, C 6 -C 10 aromatic ring or C 3 -C 7 aromatic heterocyclic ring; X is OH , COOH, CONR 2 R 3 or CONHOH; R 2 and R 3 are H, C 1 -C 4 saturated alkyl or C 6 -C 10 aromatic ring; n is an integer 1, 2, 3, 4, 5, 6 or 7. The invention can effectively orally administer the biologically active substances to organisms, and improves the stability of the biologically active medicines in the gastrointestinal tract. More importantly, the content of the active substance entering the living body has at least the amount required to produce biological effects; the present invention solves the problem of oral administration of biomacromolecular drugs, and also provides patients with a convenient way to treat diseases. |