http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104961646-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4b1eac93fa8426bfd541c9e14e11860 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48 |
| filingDate | 2015-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d3ebf5d3b13af05ee448c7141e4b166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74a469d1b5ad6eca5d583696dbbaf44f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63ba410860621380a9e5846bbdcbf41d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f04dabe2b2cf0ac6f0bd9f2a3a715dfe |
| publicationDate | 2015-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104961646-A |
| titleOfInvention | Active metabolite of mosapride and its preparation method and use |
| abstract | The invention belongs to the technical field of medicine and provides active metabolite (R)-N-[2-hydroxyl-3-(4-fluorobenzyl)amino]propyl-5-chloro-4-amino-2 of mosapride -Ethoxybenzamide (Levorotatory) and (S)-N-[2-hydroxy-3-(4-fluorobenzyl)amino]propyl-5-chloro-4-amino-2-ethoxy Benzamide (dextrorotatory) and its salts, (R,S)-N-[2-hydroxy-3-(4-fluorobenzyl)amino]propyl-5-chloro-4-amino-2-ethane Synthetic method of oxybenzamide (racemate) and its application in the preparation of gastrointestinal motility medicine; it also relates to a pharmaceutical composition containing these three active ingredients and its application in the preparation of gastrointestinal motility medicine use. The invention adopts a mouse small intestine carbon powder propulsion model to respectively investigate the gastrointestinal peristalsis-promoting effects of the levorotatory body, the dextrorotatory body and the racemic body. The results showed that at the same dose, the activity of the L-isomer was weak, and the racemate and D-isomer had obvious effects of promoting gastrointestinal motility, and the activity of the D-isomer was obviously better than that of the racemate. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017185261-A1 |
| priorityDate | 2015-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.