http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104956225-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57449 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57442 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate | 2013-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104956225-B |
| titleOfInvention | Papanicolaou test for ovarian and endometrial cancer |
| abstract | The recently developed liquid-based Papanicolaou (Pap) smear allows not only cytological evaluation but also the collection of DNA for the detection of HPV, the causative agent of cervical cancer. The present inventors tested these samples to detect somatic mutations present in the rare tumor cells that can accumulate in the cervix once shed from endometrial and ovarian cancers. A set of genes commonly mutated in endometrial and ovarian cancer was pooled and used to identify mutations in all 46 endometrial or cervical cancer tissue samples. The invention was also able to identify the same mutation in DNA from liquid Pap smears in 100% of endometrial cancers (24 of 24) and 41% of ovarian cancers (9 of 22). The present inventors developed a sequence-based approach to interrogate mutations in 12 genes in a single liquid Pap smear without prior knowledge of tumor genotype. |
| priorityDate | 2012-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 174.