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filingDate 2013-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-104955950-B
titleOfInvention The oligonucleotides of characteristic spectrum of missing the target with improvement
abstract The present invention provides the oligomers for combining RNA, by more low-affinity region and more, high affinity regions are formed for it, wherein the monomer more in high affinity regions compared to monomer used in more low-affinity region with the higher horizontal melting temperature (i.e. affinity) improved with the oligomer of RNA base pairing, wherein the raising of the melting temperature is for being used alternatingly of the DNA monomer of identical (base) sequence.Oligomer of the invention can be used for the combination to target RNA such as mRNA and non-coding RNA, and with such advantageous aspect: they are missed the target by the more low-affinity region in conjunction with compared to by more difficult for the more high affinity regions.
priorityDate 2012-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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