http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104945288-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-16 |
| filingDate | 2015-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104945288-B |
| titleOfInvention | The method that para toluene sulfonamide is prepared in the direct amidatioon of p-methyl benzenesulfonic acid |
| abstract | The method that para toluene sulfonamide is prepared in a kind of direct amidatioon of p-methyl benzenesulfonic acid, comprises the following steps：(1) anhydrous p-methyl benzenesulfonic acid is dissolved in dichloromethane, adds catalyst organic boronic and molecular sieve 5A type, control uniform stirring certain time under the conditions of 10～0 DEG C of temperature；(2) it is passed through ammonia at the temperature disclosed above to be reacted；(3) after reaction terminates, reactant liquor sucking filtration is removed carry out acid after molecular sieve, alkali, saline solution respectively washed once；(4) remove desiccant after organic faciess anhydrous sodium sulfate drying, through Distillation recovery dichloromethane solvent, and obtain para toluene sulfonamide crude product；(5) weigh after being dried through distilled water wash and use liquid-phase chromatographic analysis product purity.This method utilizes organic boronic can produce complexation with the oxygen on sulfonic acid molecules, improves the reactivity of p-methyl benzenesulfonic acid, so that amino molecule is easily combined with sulfur and generate amide, whole energy consumption of reaction is low, no spent acid discharges, and the yield of para toluene sulfonamide is 40% about. |
| priorityDate | 2015-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.