| abstract |
The invention provides an improved solid composition of oseltamivir phosphate, which comprises the pharmaceutical active ingredient oseltamivir phosphate and a disintegrating agent, wherein the disintegrating agent is low-substituted hydroxypropyl cellulose. The solid composition provided by the present invention reduces the adsorption of the disintegrant to the main drug, reduces the adsorption loss of the drug, completely dissolves the drug, and improves the drug safety and bioavailability of the drug. In addition, the present invention also investigates the adhesive The influence of the dosage on the dissolution rate provides stable quality of the solid composition, fast drug dissolution rate and high bioavailability. The invention also provides a preparation method of the oseltamivir phosphate solid composition, the method is simple and easy, and is suitable for industrial production. |