| abstract |
Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of active agents (eg, therapeutic, prophylactic, or diagnostic agents) linked to targeting moieties via linkers, have been designed, which may provide improvements spatiotemporal delivery and/or improved biodistribution of active agents. Methods of preparing the conjugates, particles and formulations are provided. Methods are provided for administering the formulations to a subject in need thereof, eg, for the treatment or prevention of cancer or infectious disease. |