http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104926906-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-004 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2015-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104926906-B |
| titleOfInvention | A kind of preparation method of 17 Alpha-hydroxy Progesterone |
| abstract | The present invention relates to a kind of preparation method of 17 Alpha-hydroxy Progesterone, the method comprises the steps: step a, carries out protection obtain etherate with the 3-carbonyl of ortho-formiate to 4-AD; Step b, reacts carbide of calcium with lower alcohol and highly basic under organic bases condition, then adds the obtained etherate of step a, is obtained by reacting 17 β-alkynyl-17 Alpha-hydroxy substituent; Step c, 17 β-alkynyl-17 Alpha-hydroxy substituent resets to obtain 17 Alpha-hydroxy Progesterone through hydration in acid condition; Steps d, carries out purifying to the product that step c obtains.The present invention is that substrate obtains 17 Alpha-hydroxy Progesterone through etherificate, ethynylation, the reaction of hydrolysis 3 step with 4-AD, and total recovery reaches more than 88%. |
| priorityDate | 2015-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.