http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104926705-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-095 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-095 |
| filingDate | 2015-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104926705-B |
| titleOfInvention | A kind of preparation method of cephalosporin nucleus intermediate |
| abstract | The invention belongs to pharmaceutical chemistry technical field, it is specifically related to the preparation method of a kind of cephalosporin nucleus intermediate, cephalosporin nucleus intermediate is to methoxy-benzyl 2 (3 phenylacetylamino 4 benzene sulfonyl sulfur generation 2 aza cyclo-butanone 1 bases) 3 chloromethyl 3 butenoates, with to methoxy-benzyl 2 (3 phenylacetylamino 4 benzene sulfonyl sulfur generation 2 aza cyclo-butanone 1 bases) 3 methyl 3 butenoates as raw material, it is in organic solvent, with copper chloride and activated carbon as catalyst, it is passed through chlorine, carries out chlorination reaction and prepare cephalosporin nucleus intermediate.Chlorination reaction of the present invention uses copper chloride and activated carbon dual catalyst to be catalyzed, reduce the generation of chlorinated secondary product, improve the yield of chlorination reaction, product G CLE 5 content obtained is high, impurity is little, and technological temperature is 20 DEG C 25 DEG C and avoids low-temp reaction demand, greatly reduce energy consumption, more can be suitable for industrial-scale production. |
| priorityDate | 2015-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.