http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104910269-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-635 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 |
| filingDate | 2015-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104910269-B |
| titleOfInvention | A method of synthesis Teriparatide |
| abstract | The present invention relates to medical synthesis fields, disclose a kind of method of synthesis Teriparatide.N-terminal coupling is had the Phe of protecting group under coupling reagent and activating reagent effect to the method and HMP Linker resins carry out esterification, obtains peptide resin 1ï¼›According to the sequence of Teriparatide amino acid sequence C-terminal to N-terminal; from peptide resin 1; under condensation reagent and activating reagent effect; remaining protected amino acid is carried out to extend coupling one by one; corresponding peptide resin is obtained after extending coupling every time; final to obtain Teriparatide resin, then acidolysis obtains Teriparatide crude product, and Teriparatide purifying crude turns acetate and obtains Teriparatide sterling.The present invention selects suitable synthetic schemes, selects HMP Linker resins as vector resin, and optimize entire synthesis technology, obtains high purity product, improves the total recovery of Teriparatide, and non-hazardous to any environment. |
| priorityDate | 2015-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 851.