http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104910036-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc4e13141d402ceb885f368dfa042348 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2015-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e4a6c4e05a91097e62c9befa4fc9736 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65edc410d6ac61db3687e06f99893229 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_403a887b78cd2d92ac5ed6c58881d6d8 |
| publicationDate | 2015-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104910036-A |
| titleOfInvention | A kind of cyclopropane α-amino acid derivative containing continuous quaternary carbon center and its synthesis method |
| abstract | The invention belongs to the technical field of pharmaceutical chemical synthesis, and discloses a cyclopropane alpha-amino acid derivative containing a continuous quaternary carbon center and a synthesis method. The synthesis method comprises the following steps: in the reactor, add N-p-toluenesulfonyl ketone hydrazone, 2-acetamidomethyl acrylate, base, phase transfer catalyst and solvent, stir and react at 70-90°C for 12- After 24 hours, cool down to room temperature after the reaction, filter the reaction solution, and distill off the solvent under reduced pressure to obtain a crude product, which is purified by column chromatography to obtain a cyclopropane α-amino acid derivative containing a continuous quaternary carbon center. The method of the invention avoids the use of transition metal catalysts, and the raw materials used are non-toxic, cheap and easy to obtain; the reaction has good adaptability to functional groups, wide adaptability to substrates, high product yield, good diastereoselectivity, and can be enlarged to a gram-level scale Production and synthesis are beneficial to industrial production, and the obtained product has a wide range of uses in the synthesis of pesticides, medicines and natural products. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107011195-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105315193-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105315193-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106674276-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110627692-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110627692-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018103509-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113387771-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107011195-B |
| priorityDate | 2015-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID163894659 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID465637233 |
Total number of triples: 25.