| abstract |
The invention provides a kind of amphiphilic block copolymer drug-loaded micelles of K + responsive targeted intracellular drug release, the drug-loaded micelles have a hydrophobic core and a hydrophilic Composition of sexual drugs, the hydrophobic drug is encapsulated in the hydrophobic core formed by the hydrophobic block of the amphiphilic block copolymer. The preparation method is as follows: the synthesized amphiphilic block copolymer and hydrophobic drug are dissolved in the co-solvent of the hydrophobic block, hydrophilic block and hydrophobic drug of the amphiphilic block copolymer, and the resulting solution is Water is added dropwise to make the concentration of the amphiphilic block copolymer 0.1-5 mg/L, and then the co-solvent is removed by dialysis, filtered and freeze-dried to obtain the drug-loaded micelles of the amphiphilic block copolymer. The drug-loaded micelles of the present invention can respond to the change of K + concentration in cancer cells to realize targeted release of drugs in cancer cells, and the effect of controlled release is outstanding. |