| abstract |
The invention discloses a method used for synthesizing glufosinate and an analogue of glufosinate by taking methylphosphoric dichloride and 2-hydroxy butane-3-nitrile as initial raw materials. According to the method, esterification is carried out so as to obtain methyl phosphite ester (I) and 2-acetyloxy-3-butenenitrile (II), intermediate (3-acetyloxy-3-cyano-propyl)-methylphosphonate (III) is obtained via Michael free radical addition, and glufosinate and the analogue (IV) are obtained via ammoniation and hydrolysis. Synthetic route of the method is short; yield is high; by-product is less; product purity is high; and the method is suitable for industrialized production. |