| abstract |
The invention discloses a 3-vinyl-quinoxalin-2(1H)-one derivative acting on FGFR-1, a preparation method and application thereof, and belongs to the field of medicinal chemistry. The present invention uses o-phenylenediamine and pyruvic acid as raw materials to obtain 3-methylquinoxalin-2(1H)-one through cyclization, and then reacts with different substituted aldehydes to obtain 3-substituted quinoxaline derivatives, and Using this as an intermediate product to obtain other types of target compounds through substitution, a total of 6 new compounds have been prepared in the present invention. The 3-vinyl-quinoxalin-2(1H)-one derivatives of the present invention have a certain inhibitory effect on experimental cells, exhibit certain anti-tumor activity, have selectivity to cells, and have good safety and Kinase inhibitory activity. |