| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2425e03c2ac444c7ef5d68bb10d611cf |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-12 |
| filingDate |
2015-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1011a3be04912dc834530fe431fa642b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16ca11094d68e2a797a40909116f047b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_200c986fb29ce0aa17e0d0e14332ef51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_274f26dbcd8bf619ed3afea4a6f6db22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3089232a4454fe12d70fcc673ac6dc7c |
| publicationDate |
2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-104892566-A |
| titleOfInvention |
Preparation method of 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene |
| abstract |
The invention relates to a preparation method of 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene, which comprises the following steps: carrying out coupling reaction on 2-bromothiophene and p-bromofluorobenzene to obtain 2-(4-fluorophenyl)thiophene; carrying out Friedel-Craft reaction on the 2-(4-fluorophenyl)thiophene and 2-methyl-5-bromobenzoic acid to obtain 5-bromo-2-methylphenyl-2-(4-fluorophenyl)thienyl ketone; and finally, carrying out reduction reaction on the 5-bromo-2-methylphenyl-2-(4-fluorophenyl)thienyl ketone to obtain the 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene. By using the cheap and accessible p-bromofluorobenzene and 2-methyl-5-bromobenzoic acid as the raw materials for synthesizing the canagliflozin intermediate, the product is easy for purification, and the method is simple to operate and has the advantages of low cost and environment friendliness. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113683593-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108017612-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105753835-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112125879-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106008453-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106008453-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108017612-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111646922-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110818679-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111646922-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106167480-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110818679-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107011316-A |
| priorityDate |
2015-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |