http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104892563-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-26 |
| filingDate | 2014-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104892563-B |
| titleOfInvention | A kind of cromoci YP3A4 enzyme spcificitys probe reaction and its application |
| abstract | The invention provides a kind of reaction of the specific probe of novel cytochrome CYP3A4 enzymes and its application：Gomisin A can detect the activity of the enzyme as the probe substrate of CYP3A4 enzymes, using gomisin A or its pharmaceutical preparation as specific probe substrate, by determining the minimizing speed of substrate gomisin A or the generating rate of the hydroxyl gomisin A of product 8 in unit interval quantification as the evaluation index of cromoci YP3A4 enzyme activity.The probe substrate also have high security, can be used as overall probe, by intravenous injection make mammal to be measured take 0.1 to 500mg/kg body weight gomisin A or its pharmaceutical preparation；The access time point in 0 to 24 hour, collects the plasma sample of tested animal；The minimizing speed of substrate gomisin A or the generating rate of the hydroxyl gomisin A of product 8 are determined, the evaluation index of whole cell pigment CYP3A4 enzymatic activitys is used as.The biological specimen of the achievable separate sources of the present invention and the qualitative assessment of internal CYP3A4 enzyme activity. |
| priorityDate | 2014-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.