| abstract |
Compounds of formula (I) Wherein X is O or S; R 1 is H, OH, SH, nitro, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , halogen, halogen C 1-6 alkyl, CN, C 1-6 -alkyl, OC 1-6 -alkyl, C 1-6 -alkyl COOH, C 1-6 -alkyl COOC 1-6 -alkyl, C 2-6 -alkenyl, C 3-10 Cycloalkyl, C 6-10 aryl, C 1-6 alkyl C 6-10 aryl, heterocyclyl, heteroaryl, CONH 2 , CONHC 1-6 alkyl, CON(C 1-6 alkyl ) 2 , OCOC 1-6 alkyl or acidic group; R 2 is defined as R 1 or R 1 and R 2 linked together can form a six-membered aromatic ring selectively substituted by up to 4 R 5 groups; R 3 is H, halogen or C (halogen) 3 ; each R 5 is defined as R 1 ; V 1 is a covalent bond or a C 1-20 alkyl group, or a C 2-20 mono- or polyunsaturated alkene base; M 1 is a cyclic group aromatic group; R 4 is H, halogen, OH, CN, nitro, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl) 2 , halogen C 1-6 alkyl group, C 1-20 alkyl group or unsaturated alkenyl group; or its salt, ester, solvate, N-oxide or prodrug; for the treatment of chronic inflammation. |