http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104892481-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-273 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-273 |
| filingDate | 2014-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104892481-B |
| titleOfInvention | A kind of technique for improving fluorochloridone Cyclization yield |
| abstract | The present invention relates to a kind of technique for improving fluorochloridone Cyclization yield; using N pi-allyl N dichloro-acetyls 3-Aminotrifluorotoluenes as raw material; anhydrous 1; 2 methylene chloride as solvent; it is 10~45ml/g raw materials to control quantity of solvent; major catalyst is done with stannous chloride; 2; 2 ' bipyridyls do co-catalyst, and it is 1: 1 with co-catalyst mol ratio to control major catalyst, and catalyst amount is 10~30mol%; controlling reaction temperature is that 70~90 DEG C of reactions to raw material disappears; reaction solution is filtered through silicagel column, dichloromethane eluent, that is, prepares fluorochloridone.Compared with prior art, the present invention only needs short silicagel column filtering, and the active compound of the fluorochloridone of content >=95% is can obtain without purifying such as distillation, recrystallizations, anti-along than >=3: 1, is cyclized yield >=95%. |
| priorityDate | 2014-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.