http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104870436-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2013-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104870436-B |
| titleOfInvention | Method for preparing (2 methyl 1 (3 methyl-benzyl) 1H benzos [d] imidazoles, 5 base) (5 base of piperidines) ketone |
| abstract | The present invention relates to the method that there is (2 methyl 1 (3 methyl-benzyl) 1H benzos [d] imidazoles, 5 base) (5 base of the piperidines) ketone and its intermediate as protease-activated receptor-2 (PAR 2) inhibitor activity for preparation.When use according to the present invention amines prepare as new intermediate compound represented by chemical formula 1 (2 methyl 1 (3 methyl-benzyl) 1H benzos [d] imidazoles, 5 base) (5 base of piperidines) ketone (its have as PAR inhibitor 2 activity and can be used for treat and prevent inflammatory diseasess) when; as protection group and Deprotection reaction need not be introduced; so reducing reactions steps on the whole; cost is saved, crystallization effectively and improves gross production rate.Additionally, the separation and purification with regard to the compound represented by chemical formula 1 for final product, can use and be applied to method for crystallising, extracting process of commercial scale synthesis etc., so as to will be very economical. |
| priorityDate | 2012-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.