http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104860975-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-022 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 |
| filingDate | 2014-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104860975-B |
| titleOfInvention | A kind of preparation method of bortezomib synthetic intermediate |
| abstract | The invention belongs to field of pharmaceutical chemistry technology, and in particular to a kind of bortezomib synthetic intermediate --- the preparation process of (R) 1- amino -3- methyl butyl boric acid pinacol ester hydrochloride.Preparation process of the present invention; the following steps are included: in ethers and/or benzene kind solvent; (R) -1-N-(terf-butylsulfinyl) -3- methyl butyl imines and connection borate at tertiary fourth oxygen copper complex (NHC) CuOt-Bu of N-heterocyclic carbine and proton donor co-catalysis; in the reactor full of argon gas or nitrogen, (R) -1-N-(terf-butylsulfinyl is obtained in 0-30 DEG C of nucleophilic addition) -3- methylbutylamine -1- boric acid pinacol ester. |
| priorityDate | 2014-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 143.