http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104857014-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-724 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 |
| filingDate | 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104857014-B |
| titleOfInvention | Application of the 2 hydroxypropyl beta cyclodextrins in the medicine for preparing the treatment chain adrenal gland white matter of brain degeneration diseases of X |
| abstract | The invention discloses a kind of 2 hydroxypropyl beta cyclodextrins（HPCD）The chain adrenal gland white matter of brain degeneration diseases of X are treated preparing（X‑ALD）Medicine in application, belong to biomedicine field.The present invention is by wild type and X ALD model mices（ABCD1 knock out mice）Inject 2 hydroxypropyl beta cyclodextrins, cell, adrenal gland and cerebellar tissue section are carried out to the cell for injecting HPCD mouse and carries out Filipin dyeing, measure its total plasma cholesterol, very-long-chain fatty acid, body weight, and carry out behaviouristics detection, as a result find, HPCD can be such that blood plasma, cerebellum, adrenal cholesterol levels drop within normal range (NR), and reduce VLCFA levels, and behaviouristics caused by alleviating X ALD mouse Nerve retrogression pathological changes is abnormal.Show that HPCD can treat X ALD based on the result, it can be used for the medicine for preparing treatment X ALD. |
| priorityDate | 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.