| abstract |
The present invention relates to a pharmaceutical composition for disease prevention or treatment, oral preparation, injection and external use for prevention or improvement of allergic skin diseases, which use GPCR19 agent or sodium taurodeoxycholate (Sodium taurodeoxycholate) and its derivatives as active ingredients Agents and cosmetic compositions. Compared with the existing steroid ointment and immunosuppressant ointment, it has the excellent effect of treating and improving atopic dermatitis, can directly reduce the amount of serum immunoglobulin IgE, which is the main factor of atopic dermatitis, and can increase It can alleviate the TH1 cytokines of allergic dermatitis, reduce the TH2 cytokines that make the symptoms of allergic dermatitis worse, and can also reduce the proliferation of fat cells, eosinophils and neutrophils in dermal cells, which can be used flexibly A pharmaceutical composition for the prevention and treatment of allergic skin diseases. |