| abstract |
The present invention relates to novel markers for hypermethylation of gene promoters in cancers.In particular the present invention relates to amethod of determining whether a tumouris developing in the aero-digestive system, or whether a subject is relapsing after treatment of such a tumour. The method comprisesdetermining the methylation level, the number of methylated CpG sites or the methylation state of CpG sites in a nucleic acid sequence in the promoter region, first exon or intron, of one or more genesselected from the group consisting of CNRIP1, SPG20, FBN1, SNCA, and INA. The method further relates to a diagnostic kit for detecting tumours in the aero-digestive tract. |