http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104844665-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 |
| filingDate | 2015-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104844665-B |
| titleOfInvention | A kind of Kdo of the low toxicity containing five fatty acid chains2The preparation and application of MPLA |
| abstract | The invention discloses a kind of Kdo of the low toxicity containing five fatty acid chains 2 The preparation and application of MPLA, belong to bioengineering field.The present invention transformation Escherichia coli, synthesized it is a kind of with special construction, low toxicity, five chain Kdo 2 MPLA, this Kdo 2 Lipoid A molecules are not connected with core polysaccharide long-chain, are only made up of two deoxidation of 2 ketone 3 octanoic acids, the single phosphoric acid of five fatty acid chains and C4 ' positions.The Kdo 2 Lipoid A has parents' property, is easy to separation and Extraction and purifying, can be carried out detection and Direct Identification, and maintains the biological immune activity of lipoid part A, and the LPS compared with wild type W3110 also has obvious attenuation, is extremely potential vaccine adjuvant.Meanwhile extraction provided by the invention and purify the Kdo 2 Lipoid A method, step is simple and clear, easily operated. |
| priorityDate | 2015-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 169.