http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104840957-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate | 2015-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104840957-B |
| titleOfInvention | Triple targeted nano granule carrier systems of the load docetaxel of Trastuzumab modification |
| abstract | A kind of triple targeted nano granule carrier systems for the load docetaxel modified the invention discloses Trastuzumab, realize triple targetings of medicine：（1）Biological target tropism, utilize the Trastuzumab monoclonal antibody molecule for being connected to nanoparticle surface；（2）Physics and chemistry targeting, the characteristics of using the polyketals in nanoparticulate carriers to acidic cancer environment sensitive, and its neutral catabolite does not change environment pH；（3）Electrostatic adsorption, using the amino group of the PEI in nanoparticulate carriers, monoclonal antibody molecule, while the adhesion between positive charge more than needed increase and tumour cell are coupled, adds cellular uptake.Nanoparticle constructed by the present invention, envelop rate 78.2%, the nm of average grain diameter 183.4, structure rounding, homogeneous grain diameter, and preparation technology is simple, security is good.Importantly, nanoparticle can significantly improve aggregation of the docetaxel in tumor locus, while there is good slow release, targeting and cytotoxicity.Triple targeted nano granule carrier systems, huge potentiality will be shown in clinical tumor chemotherapy. |
| priorityDate | 2015-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.