http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104830903-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 2015-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104830903-B |
| titleOfInvention | A kind of transgene carrier and its application based on polypeptide K12 |
| abstract | The genophore modified the present invention relates to a kind of polypeptide K12 and by K12, the polypeptide K12 sequences are：Lys‑Lys‑Lys‑Arg‑Lys‑Cys‑Gly‑Asn‑Lys‑Arg‑Thr‑Arg.First PEI is connected from poloxamer188 (P407), obtain the HMW PEI derivatives of multi-branched shape or network structure, select the small peptides of tLyP 1, it is connected with nuclear localization signal peptide NLS, synthesis is with the polypeptide K12 for targeting NRP and raising nuclear delivery ability, K12 and PEI derivatives are coupled using crosslinking technological, new non-viral gene vector P407 PEI K12 are constructed.Cytotoxicity and transfection experiment result show that not only toxicity is low by the new non-viral gene vector system P407 PEI K12 that the present invention is provided, and with stronger targeting, cell and internal transfection are superior to control group. |
| priorityDate | 2015-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.