| abstract |
The present invention provides a split-ring Rubiaceae type cyclic peptide, a pharmaceutical composition containing it as an active ingredient, which is used as an inhibitor of NF-κB signaling pathway, its preparation method and its role in the treatment and prevention of abnormal activation of NF-κB signaling pathway Drug applications related to inflammatory diseases and cancer. The ring-opening Rubiaceae type cyclic peptide of the present invention is a kind of N-methyl-L-α-tyrosine substituted by 1 D-α-alanine, 2 L-α-alanines and 3 A cyclic compound formed by condensation of acids through peptide bonds. The preferred structural formula is (1-3) of the ring-opening Rubiaceae type cyclic peptide, which is an inhibitor of NF-κB signaling pathway. |