| abstract |
Compounds of formula I are HIV reverse transcriptase inhibitors, wherein R1, R2, RE , L, M and Z are as defined herein. The compounds of formula I and their pharmaceutically acceptable salts can be used for inhibiting HIV reverse transcriptase, preventing and treating HIV infection, preventing AIDS, delaying the onset or development of AIDS and treating AIDS. Said compounds and their salts can be used as components of pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines, (I). |