http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104817544-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 |
| filingDate | 2015-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104817544-B |
| titleOfInvention | Tetrahydroindole-4-ketoxime drug, preparation method and application thereof |
| abstract | The invention relates to a tetrahydroindole-4-ketoxime drug, the structural formula of which is shown as the specification. The preparation method includes: taking tetrahydrobenzoindole-4-one (intermediate 1) as the raw material, subjecting the raw material to condensation with hydroxylamine hydrochloride to obtain corresponding ketoxime (intermediate 2), carrying out separation and purification to obtain a cis-ketoxime isomer and a trans-ketoxime isomer respectively; subjecting the ketoxime intermediate 2 and propargyl bromide to alkylation to obtain propargyl oxime ether (intermediate 3), and finally, subjecting the intermediate 3 and different types of raw material azide R＜4＞N3 to copper catalyzed cycloaddition reaction to synthesize a 1, 2, 3-triazole substituted indolocyclohexanone oxime drug 4. The invention also applies the drug to preparation of medicines treating gastric cancer, breast cancer, and liver cancer. |
| priorityDate | 2015-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 137.