http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104817486-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 |
| filingDate | 2015-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104817486-B |
| titleOfInvention | A kind of synthetic method of ramipril intermediate |
| abstract | The invention discloses a kind of synthetic methods of the Ramipril key intermediate shown in Formulas I：Amides compound shown in Formula IV compound represented, Formula V carries out condensation reaction production IV compounds represented；Formula IV compound represented carries out addition reaction with the olefinic amine compound shown in formula III, Formula II compound represented is made, cyclization and esterification is hydrolyzed with benzylalcohol in Formula II compound represented in an acidic solution, then reduced through reducing agent, the Ramipril key intermediate shown in Formulas I is made.Present invention process is simple, reaction condition is mild, avoids heavy metal pollution, the use of chlorinating agent, post processing is easy, and safe operation is reliable, and the three wastes are small. |
| priorityDate | 2015-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 111.